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- Title
First-generation versus second-generation antipsychotic drugs for depression in schizophrenia.
- Authors
Corbo, M.; Acciavatti, T.; Marini, S.; Cinosi, E.; Di Tizio, L.; Di Caprio, L.; Viceconte, D.; Matteo, L.; Giuseppe, D.I.; Martinotti, G.; Di Giannantonio, M.
- Abstract
Introduction A certain degree of depressive symptoms is common in schizophrenic patients. The assessment and treatment of depressive symptoms in schizophrenia is clinically challenging. Objectives We conducted a cross-sectional study to investigate the depressive dimension of schizophrenic patients. Aims The aim was to evaluate the effect of pharmacotherapy on depressive symptomatology. Methods Thirty-four outpatients (18-65 years old) with stable schizophrenia in monotherapy with FGAs or SGAs. We evaluated: depressive symptoms with Calgary Depression Scale for Schizophrenia; positive and negative symptoms (with Positive and Negative Symptom Scale); neurocognition (with Matrics Cognitive Consensus Battery); social cognition (with Facial Emotional Identification Test); social functioning (with Personal and Social Performance Scale and with UCSD Performance-based Skills Assessment). Collected data underwent statistical analyses. Results A SGAs therapy was associated with: lower depressive symptoms (mean SGAs group = 4.0; mean FGAs group = 7.86, P < 0.05); lower mean positive symptoms (mean SGAs group = 12.65; mean FGAs group = 17.43, P < 0.05); lower negative symptoms (mean SGAs group = 21.35; mean FGAs group = 29.07, P < 0.05); lower scores on the PANSS-total (mean SGAs group = 71.05; mean FGAs group = 91.86, P < 0.01). After correction for multiple variables, the SGAs group still had significantly lower values towards the FGAs group ( P < 0.05). Conclusions Our study support the notion that switch from a FGA to a SGA could be a relatively simple first-step for the treatment of this condition. Atypical antipsychotics might exercise antidepressant effects with different potential mechanism including: remission of a FGA-induced depression and action on of 5-hydroxytryptamine, dopamine [other than postsynaptic D2], and α1-noradrenergic receptor sites.
- Subjects
MENTAL depression; THERAPEUTICS; ANTIPSYCHOTIC agents; PEOPLE with schizophrenia; DRUG therapy; OUTPATIENT medical care; CROSS-sectional method
- Publication
European Psychiatry, 2016, Vol 33, pS290
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1016/j.eurpsy.2016.01.620