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- Title
PW01-39 - Characteristics of patients with hypomanic symptoms presenting a current major depressive episode identified with the HCL-32 patient questionnaire
- Authors
Vieta, E.; Angst, J.; Azorin, J.-M.; Bowden, C.L.; Perugi, G.; Young, A.H.
- Abstract
Objectives: To evaluate the extent of hypomanic symptoms in patients presenting with a current major depressive episode (MDE) and to identify characteristics differentiating patients with hypomanic symptoms from those with pure unipolar depression, using the HCL-32 self-assessment tool. Methods: This cross-sectional diagnostic study was performed in eighteen countries. Community- and hospital- based psychiatrists included consecutively all consulting adult patients with a diagnosis of MDE and completed a questionnaire on sociodemographic variables, diagnosis, medical history, treatment and comorbid psychiatric disorders. Each patient completed the Hypomania Self-Rating Scale (HCL-32 R2), and those scoring ≥14 were assigned a diagnosis of bipolar disorder. The frequency of study variables in the bipolar disorder (BD) and unipolar depression subgroups were compared. Results: A total of 5635 patients were included. Overall, 1645(39%) had received a diagnosis of BD, 703(16%) fulfilled DSM-IV-TR criteria for BD and 2942(54%) scored ≥14 on the HCL-32. Patients scoring ≥14 on the HCL-32 were significantly more likely to have experienced a mood switch in response to antidepressants (OR:3.4), a family history of bipolarity (OR:2.4), comorbid substance abuse (OR:2.1) or borderline personality disorder (OR:1.7) and current mixed-state symptoms (OR:1.5). Conclusions: In patients with DSM-IV MDE self-assessed, hypomanic symptoms were present in 54% of patients, whereas only 16% fulfilled DSM-IV criteria for bipolar disorder. However, these patients presented features recognised to be associated with bipolar disorder. The presence of bipolarity in patients presenting with a major depressive disorder may be frequent and use of this questionnaire would contribute to improve awareness and prompt better diagnosis.
- Subjects
MENTAL depression; HYPOMANIA; CROSS-sectional method; PSYCHIATRISTS; BIPOLAR disorder; ANTIDEPRESSANTS; PATHOLOGICAL psychology
- Publication
European Psychiatry, 2010, Vol 25, p1458
- ISSN
0924-9338
- Publication type
Abstract
- DOI
10.1016/S0924-9338(10)71441-3