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- Title
miR-508-3p suppresses the development of ovarian carcinoma by targeting CCNA2 and MMP7.
- Authors
Guo, Fei; Zhang, Kai; Li, Meiyue; Cui, Lei; Liu, Guoyan; Yan, Ye; Tian, Wenyan; Teng, Fei; Zhang, Yanfang; Gao, Chao; Gao, Jinping; Wang, Yingmei; Xue, Fengxia
- Abstract
Ovarian cancer is the most lethal gynecological tumor, and the 5-year survival rate is only ~40%. The poor survival rate is due to cancer diagnosis at an advanced stage, when the tumor has metastasized. A better understanding of the molecular pathogenesis of tumor growth and metastasis is needed to improve patient prognosis. MicroRNAs (miRs) regulate carcinogenesis and development of cancers. However, the role of miR-508-3p in ovarian cancer remains largely unknown. Thus, the present study aimed to investigate the possible functions of miR-508-3p in the modulation of development of ovarian cancer. The results of the present study demonstrated that miR-508-3p mimics inhibited ovarian cancer cell proliferation, migration and invasion. Reporter gene assay results demonstrated that miR-508-3p suppressed cancer cell proliferation by directly targeting the 3′-untranslated region (UTR) of cyclin A2 (CCNA2) and suppressed migration and invasion by directly targeting the 3′-UTR of matrix metallo-proteinase 7 (MMP7). In addition, high CCNA2 and MMP7 expression levels were associated with low miR-508-3p expression in ovarian cancer tissues. Furthermore, miR-508-3p and CCNA2 were independent predictors for overall survival in patients with ovarian cancer. To the best of our knowledge, this is the first study to demonstrated that miR-508-3p suppressed ovarian cancer development by directly targeting CCNA2 and MMP7. The results of this study suggested the potential value of miR-508-3p and CCNA2 as prognostic indicators and therapeutics for ovarian cancer.
- Publication
International Journal of Oncology, 2020, Vol 57, Issue 1, p264
- ISSN
1019-6439
- Publication type
Article
- DOI
10.3892/ijo.2020.5055