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- Title
Oxidative Modification of Rat Blood Proteins after Lesioning of Capsaicin-Sensitive Nerves and Changes in Nitric Oxide Levels.
- Authors
Tolochko, Z.; Spiridonov, V.
- Abstract
Oxidative modification of blood proteins in rats after lesioning of afferent nerves with capsaicin (150 mg/kg, s.c.) and changes in nitric oxide (NO) contents were studied in terms of levels of protein carbonyl derivatives. Deafferentation of capsaicin-sensitive nerves induced increases in the level of protein carbonyl derivatives. Increases in NO levels using L-arginine did not alter measures of the oxidative modification of proteins after lesioning of capsaicin-sensitive innervation. A similar lack of effect was seen after blockade of neuronal NO synthase (n-NOS) by the selective inhibitor 7-nitroindazole (7-NI). Increases in markers of oxidative destruction of proteins in capsaicin-treated animals were seen after blockade of NO synthesis by the nonselective inhibitor L-NAME. These results show that deafferentation of capsaicin-sensitive nerves induces oxidative modification of proteins and that this process involves NO.
- Subjects
OXIDATION-reduction reaction; CAPSAICIN; NITRIC-oxide synthases; CARBONYL compounds; ACTIVE oxygen in the body; LABORATORY rats
- Publication
Neuroscience & Behavioral Physiology, 2011, Vol 41, Issue 5, p479
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-011-9440-7