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- Title
Clinicopathological features observed in rats exposed to leachates from a municipal dump site in Nigeria.
- Authors
Balogun, Temitope; Morenikeji, Olajumoke; Emikpe, Benjamin; Oyelowo, Oluwakemi; Oyebanji, Victor
- Abstract
As a result of increasing urban settlements across cities in most developing countries, waste disposal has become a burden and a serious threat to public health. This study was carried out to determine the organopathic effects of leachate from a municipal dumpsite (3.848oE, 7.461oN) in Nigeria. Wistar rats were gavaged with graded concentrations (0, 1, 2.5, 5, 10 & 25%) of leachate for 30 days. Clinical signs, hematological, organosomatic indices, heavy metal residues in tissues and blood were evaluated after exposure. Data were analyzed using one way ANOVA and the Duncan multiple range test (p < 0.05). Heavy metal concentrations in leachates were found to be higher (205 times) than acceptable limits. With an increase of leachate concentration, residues in blood and liver increased with the corresponding severity of muscle stiffness, dyspnea and diarrhea. Also, significant macrocytic hypochromic anemia, heterophil-lymphocyte ratio and leucopenia were observed while the organosomatic index (p < 0.05), aspartate platelet ratio and serum albumin decreased. Histology of the liver revealed progressive concentration-dependent hepatocellular degeneration and necrosis, while the kidney uniformly showed tubular epithelia damage. This study highlights the risks that residents of such areas are exposed to. Hence, proper municipal waste management program should be implemented.
- Publication
Zoology & Ecology, 2018, Vol 28, Issue 1, p50
- ISSN
2165-8013
- Publication type
Article
- DOI
10.1080/21658005.2017.1400741