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- Title
Glycaemic control, disease duration and β-cell function in patients with Type 2 diabetes in a Swedish community. Skaraborg Hypertension and Diabetes Project.
- Authors
Östgren, C. J; Lindblad, U; Ranstam, J; Melander, A; Råstam, L
- Abstract
Abstract Aims To examine determinants for glycaemic control in primary care patients with Type 2 diabetes. Methods In a community-based surveillance of primary care patients with Type 2 diabetes, 190 men and 186 women were consecutively identified and examined for cardiovascular risk factors. Insulin resistance and β-cell function were estimated using homeostasis model assessment (HOMA). Good glycaemic control was defined as HbA1c < 6.5%. Results Following adjustment for age and gender, HbA1c ≥ 6.5% was associated with duration of diabetes (10.6 vs. 6.4 years, P < 0.001), lower levels of serum insulin (6.3 vs. 8.0 mU/l, P = 0.012), higher serum triglyceride levels (2.0 vs. 1.7 mmol/l, P = 0.002) and impairment of β-cell function (HOMA index 19.5 vs. 45.8, P < 0.001). The association between HbA1c levels and duration remained with adjustment for age, gender, waist–hip ratio (WHR) and serum triglycerides (odds ratio (OR) for HbA1c ≥ 6.5% by 5 years diabetes duration = 1.7; 95% confidence interval (CI) 1.4–2.1) but was lost following additional adjustment for β-cell function (OR for HbA1c ≥ 6.5%= 1.3; 95% CI 0.96–1.7). In a separate linear regression with β-cell function as the dependent variable there was a significant association with HbA1c after adjustments for differences in age, gender, WHR, serum triglyceride levels and diabetes duration (P < 0.001). Conclusions Increasing HbA1c by time was associated with declining β-cell function. Diabet. Med. 19, 125–129 (2002).
- Subjects
SWEDEN; TYPE 2 diabetes; BLOOD sugar monitoring
- Publication
Diabetic Medicine, 2002, Vol 19, Issue 2, p125
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.2002.00661.x