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- Title
Amplification and overexpression of E2F3 in human bladder cancer.
- Authors
Feber, Andrew; Clark, Jeremy; Goodwin, Graham; Fletcher, Anne; Edwards, Sandra; Flohr, Penny; Falconer, Alison; Dennis, Nening; Huddart, Robert; Dodson, Andrew R.; Smith, Paul H.; Roe, Toby; Kovacs, Gyula; Fisher, Cyril; Wooster, Richard; Foster, Christopher S.; Cooper, Colin S.
- Abstract
We demonstrate that, in human bladder cancer, amplification of the E2F3 gene, located at 6p22, is associated with overexpression of its encoded mRNA transcripts and high levels of expression of E2F3 protein. Immunohistochemical analyses of E2F3 protein levels have established that around one-third (33/101) of primary transitional cell carcinomas of the bladder overexpress nuclear E2F3 protein, with the proportion of tumours containing overexpressed nuclear E2F3 increasing with tumour stage and grade. When considered together with the established role of E2F3 in cell cycle progression, these results suggest that the E2F3 gene represents a candidate bladder cancer oncogene that is activated by DNA amplification and overexpression.Oncogene (2004) 23, 1627-1630. doi:10.1038/sj.onc.1207274 Published online 29 December 2003
- Subjects
BLADDER tumors; DNA microarrays; ONCOGENES; IMMUNOHISTOCHEMISTRY; CELL cycle
- Publication
Oncogene, 2004, Vol 23, Issue 8, p1627
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1207274