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- Title
Atrial and Brain Natriuretic Peptides Enhance Dopamine Accumulation in Cultured Rat Hypothalamic Cells Including Dopaminergic Neurons.
- Authors
Kadowaki, Kozo; Hirota, Kenji; Koike, Koji; Ohmichi, Masahide; Miyake, Akira; Tanizawa, Osamu
- Abstract
Dopamine accumulation in hypothalamic cells by atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) was analyzed using newborn rat hypothalamic cells in culture. Both ANP and BNP caused a dose-dependent increase in [3H]-dopamine accumulation in the cells. ANP increased [3H]-dopamine accumulation significantly within 20 min. The effects of ANP and BNP on dopamine accumulation paralleled an increase in intracellular cGMP concentration. (Bu)2-cGMP and sodium nitroprusside, a stimulator of the soluble form of guanylate cyclase, also enhanced [3H]-dopamine accumulation. ANP had no effect on efflux of [3H] radioactivity after [3H]-dopamine uptake. These results suggest that a change in cGMP is one of the intermediate steps in dopamine accumulation in hypothalamic cells by ANP and BNP. Copyright © 1992 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1992, Vol 56, Issue 1, p11
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000126202