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- Title
Effect of Somatostatin and Dopaminergic Agents on Bovine Pituitary Phosphodiesterase Activity.
- Authors
Nagasaka, Akio; Hidaka, Hiroyoshi; Nakagawa, Hifumi; Nakai, Akira; Ohyama, Takako; Aono, Toshihiro; Masunaga, Rumi; Iwase, Katsumi
- Abstract
The effects of somatostatin and dopaminergic agents on pituitary cyclic nucleotide phosphodiesterases that had been partially purified through DEAE cellulose column chromatography were studied. Somatostatin, .L-dopa, dopamine and CB-154(2-bromo-α-ergocriptine) competitively inhibited the pituitary cyclic AMP phosphodiesterase activity, especially that of the low Km enzyme. This inhibition was most potent in the case of somatostatin and CB-154. Copyright © 1986 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1986, Vol 43, Issue 3, p410
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000124557