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- Title
In vivo anticancer activity of vanillin semicarbazone
- Authors
Ali, Shaikh M Mohsin; Azad, M Abul Kalam; Jesmin, Mele; Ahsan, Shamim; Rahman, M Mijanur; Khanam, Jahan Ara; Islam, M Nazrul; Shahriar, Sha M Shahan
- Abstract
Abstract: Objective: To evaluate the anticancer activity of vanillin semicarbazone (VSC) against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. Methods: The compound VSC at three doses (5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight, enhancement of survival time as well as the changes in depleted hematological parameters. All such parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg (i.p.). Results: Among the doses studied, 10 mg/kg (i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg (i.p.). The host toxic effects of VSC was found to be negligible. Conclusions: It can be concluded that VSC can therefore be considered as potent anticancer agent.
- Subjects
ANTINEOPLASTIC agents; VANILLIN; AZIDES; ASCITES tumors; CANCER cells; BLEOMYCIN; LABORATORY mice
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2012, Vol 2, Issue 6, p438
- ISSN
2221-1691
- Publication type
Article
- DOI
10.1016/S2221-1691(12)60072-0