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- Title
Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Residual Tumor Cells at the Surgical Margins.
- Authors
Keating, Jane; Okusanya, Olugbenga; Jesus, Elizabeth; Judy, Ryan; Jiang, Jack; Deshpande, Charuhas; Nie, Shuming; Low, Philip; Singhal, Sunil; Keating, Jane J; Okusanya, Olugbenga T; De Jesus, Elizabeth
- Abstract
<bold>Purpose: </bold>During lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to pulmonary adenocarcinomas could enhance residual tumor during resection.<bold>Procedures: </bold>Mice with flank tumors received a contrast agent targeting folate receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three humans with lung adenocarcinoma.<bold>Results: </bold>The peak tumor-to-background ratio (TBR) of murine tumors was 3.9. Fluorescence peaked at 2 h and was not improved beyond 0.1 mg/kg. Traditional inspection identified 30% of mice with positive margins. Molecular imaging identified an additional 50% of residual tumor deposits (p < 0.05). The fluorescent probe visually enhanced all human tumors with a mean TBR of 3.5.<bold>Conclusions: </bold>Molecular imaging is an important adjunct to traditional inspection to identify surgical margins after tumor resection.
- Subjects
ADENOCARCINOMA; LOBULAR carcinoma; SURGICAL excision; FLUORESCENCE; CANCER cells; CARCINOGENESIS; ANIMAL experimentation; CELL lines; DIAGNOSTIC imaging; LUNGS; LUNG tumors; INTRAOPERATIVE care; MICE; MOLECULAR diagnosis; RESEARCH funding; TUMOR antigens; FLUORESCENT dyes
- Publication
Molecular Imaging & Biology, 2016, Vol 18, Issue 2, p209
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-015-0878-9