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- Title
HUMAN LIMB DEVELOPMENT ON THE 3 AXES OF COORDINATES. MOLECULAR ETIOLOGY OF POLYDACTYLY.
- Authors
Vesa, Cosmin Mihai; Mekeres, Florica; Popa, Loredana Mădălina; Vidican, Mădălina; Maghiar, Adriana; Jurca, Claudia; Bembea, Marius
- Abstract
Limb development is a very complex process, not completely understood yet. There are multiple genes implicated during the process and the complexity of limb development consists in the interaction of these genes through transcription factors. The responsible structures for limb development are the centres of signalling, areas of the limb bud where gene transcription has a high rate and transcription factors determine the pattern of the cells situated nearby. The Apical Ectodermal Ridge (AER) is the signalling centre responsible for the proximal-distal development of the limb; the Zone of Polarizing Activity (ZPA) is responsible for the patterning of the limb on the anterior-posterior axis. The non -AER ectoderm is responsible for the dorsal-ventral pattering.
- Subjects
PHYSIOLOGY of the anatomical extremities; DEVELOPMENTAL biology; ETIOLOGY of diseases; POLYDACTYLY; CELL communication
- Publication
Analele Universitatii din Oradea, Fascicula Ecotoxicologie, Zootehnie si Tehnologii în Industria Alimentara, 2017, Vol 16, Issue Part A, p217
- ISSN
1583-4301
- Publication type
Article