We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
NDDVD: an integrated and manually curated Neurodegenerative Diseases Variation Database.
- Authors
Yang, Yang; Xu, Chen; Liu, Xingyun; Xu, Chao; Zhang, Yuanyuan; Shen, Li; Vihinen, Mauno; Shen, Bairong
- Abstract
Neurodegenerative diseases (NDDs) are associated with genetic variations including point substitutions, copy number alterations, insertions and deletions. At present, a few genetic variation repositories for some individual NDDs have been created, however, these databases are needed to be integrated and expanded to all the NDDs for systems biological investigation. We here build a relational database termed as NDDVD to integrate all the variations of NDDs using Leiden Open Variation Database (LOVD) platform. The items in the NDDVD are collected manually from PubMed or extracted from the existed variation databases. The cross-disease database includes over 6374 genetic variations of 289 genes associated with 37 different NDDs. The patterns, conservations and biological functions for variations in different NDDs are statistically compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0. URL : http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0
- Subjects
NEURODEGENERATION; GENETIC databases; DATA extraction
- Publication
Database: The Journal of Biological Databases & Curation, 2018, Vol 2018, p1
- ISSN
1758-0463
- Publication type
Article
- DOI
10.1093/database/bay018