We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Recent Updates in the Prevention of Nonalcoholic Fatty Liver Disease.
- Authors
El-Kassas, Mohamed; Awad, Abeer; Méndez-Sánchez, Nahum
- Abstract
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the leading causes of hepatic fibrosis and liver-related mortality worldwide, despite efficient hepatitis B and C antiviral therapies that have dramatically lowered the disease load. Although significant efforts have been exerted to understand the molecular basis of disease pathogenesis, there are currently few therapeutic alternatives available for NAFLD-associated fibrosis. Thus, NAFLD prevention is critical before the development of disease-related complications. In this context, there is a tremendous substantial global burden on public health systems to actively search for effective preventive and therapeutic targets for NAFLD. In this review, we highlight the current strategies to prevent progression and poor outcomes of NAFLD and to avoid complications associated with disease fibrosis, notably cirrhosis, portal hypertension, and liver cancer. We discuss different nonpharmacological measures, such as lifestyle modifications (weight loss, exercise, healthy diet) and other pharmacological interventions that could prevent NAFLD.
- Subjects
NON-alcoholic fatty liver disease; HEPATIC fibrosis; DISEASE complications; PORTAL hypertension; HEPATITIS B
- Publication
Gene Expression (1052-2166), 2023, Vol 22, Issue 1, p19
- ISSN
1052-2166
- Publication type
Article
- DOI
10.14218/GE.2022.00005S