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- Title
Impaired myocyte function in vitro incubated with sera from patients with myocarditis.
- Authors
Drude, L.; Wiemers, F.; Maich, B.
- Abstract
Sera positive for antimyolemmal antibodies (AMLAs) from patients with acute biopsy-proven myocarditis exerted a cytotoxic effect on cardiocytes stimulated in vitro. Using an edge-detecting system, contraction amplitude and contraction velocity were altered after the addition of AMLA-positive sera when compared to sera from healthy controls. Antibodies alone did not change the functional parameters. Only the presence of complement and heart-reactive antibodies mediated the detrimental effects. This suggests that a complement-mediated antibody-dependent immune mechanism is operative in human myocarditis.
- Publication
European Heart Journal, 1991, Vol 12, Issue suppl_D, p36
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/12.suppl_d.36