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- Title
Engineering the Stereochemistry of Cephalosporin for Specific Detection of Pathogenic Carbapenemase-Expressing Bacteria.
- Authors
Shi, Haibin; Cheng, Yunfeng; Lee, Kyung Hyun; Luo, Robert F.; Banaei, Niaz; Rao, Jianghong
- Abstract
Reported herein is the design of fluorogenic probes specific for carbapenem-resistant Enterobacteriaceae (CRE) and they were designed based on stereochemically modified cephalosporin having a 6,7-trans configuration. Through experiments using recombinant b-lactamase enzymes and live bacterial species, these probes demonstrate the potential for use in the specific detection of carbapenemases, including metallob- lactamases in active bacterial pathogens.
- Subjects
CARBAPENEMS; ENTEROBACTERIACEAE; CEPHALOSPORINS; BETA lactam antibiotics; ANTIBACTERIAL agents; BETA lactamases
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 31, p8113
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201402012