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- Title
A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues.
- Authors
Long, Dong; Marshall, Christopher B.; Bouvignies, Guillaume; Mazhab‐Jafari, Mohammad T.; Smith, Matthew J.; Ikura, Mitsuhiko; Kay, Lewis E.
- Abstract
Conformational Exchange: Small GTPases, such as Ras and Rheb, exchange between major and minor conformers when bound to GTP, with different functional properties for each state (see picture). Two‐dimensional 15N CEST NMR spectroscopy is used to quantify the exchange parameters for both Ras and Rheb complexed with physiological GTP and the analogues GTPγS and GppNHp.
- Subjects
GUANOSINE triphosphatase; RAS proteins; NUCLEOTIDES; NUCLEIC acids; GUANOSINE
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 41, p10771
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201305434