We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polymer Nanofiber-Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells.
- Authors
Hou, Shuang; Zhao, Libo; Shen, Qinglin; Yu, Juehua; Ng, Charles; Kong, Xiangju; Wu, Dongxia; Song, Min; Shi, Xiaohong; Xu, Xiaochun; OuYang, Wei‐Han; He, Rongxian; Zhao, Xing‐Zhong; Lee, Tom; Brunicardi, F. Charles; Garcia, Mitch André; Ribas, Antoni; Lo, Roger S.; Tseng, Hsian‐Rong
- Abstract
Confined to one cell: A method to detect and isolate single circulating melanoma cells (CMCs; see figure) has been produced by integrating a polymer‐nanofiber‐embedded nanovelcro cell‐affinity assay with a laser microdissection (LMD) technique. This method is able to separate CMCs from normal white blood cells (WBCs) and sequence individual cells for a specific mutation related to cancer progression, allowing for more personalized cancer therapy.
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 12, p3379
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201208452