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- Title
Role of nitric oxide signaling in the antidepressant mechanism of action of ketamine: A randomized controlled trial.
- Authors
Bevilacqua, Laura; Charney, Alex; Pierce, Charlotte R; Richards, Samantha M; Jha, Manish K; Glasgow, Andrew; Brallier, Jess; Kirkwood, Katherine; Bagiella, Emilia; Charney, Dennis S; Murrough, James W
- Abstract
Ketamine is an N-methyl-D-aspartate receptor antagonist with rapid antidepressant effects. Studies suggest that inhibition of nitric oxide synthesis plays a role in the mechanism of action of ketamine. This randomized, placebo-controlled study investigated whether co-administration of sodium nitroprusside, a nitric oxide donor, compared to placebo, would attenuate the antidepressant and dissociative effects of ketamine. Sixteen ketamine responders were randomized to a double-blind infusion of ketamine co-administered with placebo or sodium nitroprusside. Our findings show no difference between the two conditions suggesting that the nitric oxide pathway may not play a primary role in ketamine's antidepressant or dissociative effects. The study is registered at clinicaltrials.gov (NCT03102736).
- Subjects
KETAMINE; ANTIDEPRESSANTS; RANDOMIZED controlled trials; NITRIC oxide; METHYL aspartate receptors; SODIUM nitroferricyanide; RESEARCH; RESEARCH methodology; CELL receptors; EXCITATORY amino acid antagonists; MEDICAL cooperation; EVALUATION research; CELLULAR signal transduction; CARDIOVASCULAR agents; COMPARATIVE studies; MENTAL depression; BLIND experiment
- Publication
Journal of Psychopharmacology, 2021, Vol 35, Issue 2, p124
- ISSN
0269-8811
- Publication type
journal article
- DOI
10.1177/0269881120985147