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- Title
Investigation of Antifungal activity of Teucrium polium L. against Candida albicans.
- Authors
Rezaei, Elham; Madani, Mahboobeh
- Abstract
Introduction: Medicinal plants such as Teucrium polium L. are believed to be an important source of new chemical substances with potential therapeutic effects. The main goal of this study is to evaluate the mechanism of antifungal potency of T. polium L. compared to amphotericin B against Candida albicans. Materials and Methods: T. polium L. was collected from Isfahan, dried and powdered. Then methanol extract was prepared. C. albicans was added to extract, and the presence of sodium, potassium, glucose and amino acids were determined by flame photometer, autoanalyzer and HPLC. Result: Results showed that Sodium, potassium, glucose and amino acids were released from C. albicans. So ethanolic extract of T. polium has inhibitory effect on the growth of C. albicans. Based on the HPLC results, 2181.232, 330.935, and 296.374 mg/ml of glutamine, glycine, and glutamic acid were in extract respectively. Conclusion: The results suggest that antifungal mechanism of T. polium against C. albicans is similar to amphotericin B.
- Subjects
IRAN; CANDIDA albicans; CONFERENCES &; conventions; PLANT extracts
- Publication
Current Medical Mycology, 2018, Vol 4, p163
- ISSN
2423-3439
- Publication type
Article
- DOI
10.18502/cmm.4.S1.2018.180