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- Title
Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru.
- Authors
Ponce, Mario; Ugarte-Gil, Cesar; Zamudio, Carlos; Krapp, Fiorella; Gotuzzo, Eduardo; Seas, Carlos
- Abstract
The effectiveness of the World Health Organization's (WHO) treatment category II regimen for tuberculosis in 124 patients was compared to that of 1147 patients receiving treatment category I in Lima, Peru following WHO's guidelines. Drug susceptibility test was available for 85% of patients. Prevalence of multi drug resistance and streptomycin resistance were 5.1% and 20.7%, respectively. Overall cure rate for regimen II was lower than that of regimen I: 67.8% (95% CI: 58.9–75.6.) vs 77.8% (95% CI: 75.3–80.2), p = 0.014. Multi-drug resistance exerted a profound effect on cure rates in both regimens. Our results support the phasing-out of treatment category II regimen in Peru.
- Subjects
LIMA (Peru); TUBERCULOSIS treatment; TUBERCULOSIS patients; DRUG resistance in bacteria; STREPTOMYCIN
- Publication
Transactions of the Royal Society of Tropical Medicine & Hygiene, 2012, Vol 106, Issue 8, p508
- ISSN
0035-9203
- Publication type
Article
- DOI
10.1016/j.trstmh.2012.05.008