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- Title
Treatment of stage IIIB cervical cancer with Californium-252 fast-neutron brachytherapy and external photon therapy.
- Authors
Gallion, Holly H.; Maruyama, Yosh; van Nagell, John R.; Donaldson, Elvis S.; Rowley, Kenneth C.; Yoneda, Justine; Beach, Joseph L.; Powell, Deborah E.; Kryscio, Richard J.; Gallion, H H; Maruyama, Y; van Nagell, J R Jr; Donaldson, E S; Rowley, K C; Yoneda, J; Beach, J L; Powell, D E; Kryscio, R J
- Abstract
From January 1977 to July 1984, 32 patients with Stage IIIB cervical cancer were treated at the University of Kentucky Medical Center by a combination of outpatient neutron brachytherapy and external pelvic radiation. These patients received 4500 to 5000 rad external photon therapy and two or three outpatient Californium-252 (252Cf) implants, plus sidewall boost irradiation. Treatment results were compared retrospectively to those obtained in a historical control group of patients with Stage IIIB cervical cancer treated with external radiation and conventional photon brachytherapy from 1972 to 1976. Local or regional tumor recurrence developed in 53% of patients treated with neutron therapy and an additional 9% experienced distant metastases. Thirty-eight percent of patients remain free of disease 12 to 96 months (mean, 51 months) after therapy. The 2-year and 5-year survival rates of patients treated with neutron therapy were 53% and 36%, which were not significantly different than those obtained with photon brachytherapy (2-year survival, 61%; 5-year survival, 34%). Complications of neutron therapy were minimal and included proctitis (19%) and vaginal stenosis (9%). There were no cases of enteric fistulae. Outpatient neutron brachytherapy was cost effective and was well tolerated by patients.
- Publication
Cancer (0008543X), 1987, Vol 59, Issue 10, p1709
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19870515)59:10<1709::AID-CNCR2820591005>3.0.CO;2-V