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- Title
Restoration of defective EAG-rosetting capacity of cancer patient neutrophils by levamisole.
- Authors
Patrone, Franco; Dallegri, Franco; Pistoia, Vito; Ghio, Riccardo; Sacchetti, Carlo; Patrone, F; Dallegri, F; Pistoia, V; Ghio, R; Sacchetti, C
- Abstract
Levamisole, used in vitro at therapeutic concentrations, was found able to restore the defective Fc-receptor activity of cancer patient neutrophils. In addition, the drug prevented the inhibition of normal neutrophils Fc-receptor function by cancer patient sera. The neutrophil Fc-receptor function was also restored in six of seven cancer patients after in vivo administration of levamisole (2.5 mg/Kg/day for 3 days). Due to the central role played by the Fc-receptor function in host defence mechanisms, including phagocytosis as well as antibody dependent cellular cytotoxicity, the capacity of levamisole to restore defective neutrophil Fc-receptor function in cancer patients could contribute to the "immunomodulating" effect of the drug.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 8, p1668
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850415)55:8<1668::AID-CNCR2820550810>3.0.CO;2-M