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- Title
The coexistence of nodular and diffuse patterns in nodular non-Hodgkin's lymphomas: significance and clinicopathologic correlation.
- Authors
Warnke, Roger A.; Kim, Hun; Fuks, Zvi; Dorfman, Ronald F.; Warnke, R A; Kim, H; Fuks, Z; Dorfman, R F
- Abstract
One hundred and twenty-six cases of nodular lymphoma have been classified cytologically by the criteria of Rappaport, and have been divided into three architectural groups, based on the degree of nodularity. Eighty-five percent of the patients have been followed for at least 5 years after initial therapy. Analysis of actuarial survival curves reveals that patients in the poorly differentiated lymphocytic and mixed histiocytic-lymphocytic categories with the three architectural patterns ("nodular only," "nodular with focal diffuse," and "nodular with diffuse") have similar long-term and disease-free survivals. Nevertheless, any degree of nodularity imparts a more favorable prognosis than diffuse lymphoma of coreresponding cell type. In the small number of patients with a nodular lye than in the other two histiocytic type, associated with diffuse areas, the prognosis is less favorable than in the other two histologic groups. Thus, a nodular lymphoma of so-called histiocytic type with diffuse areas may behave more like a diffuse than nodular lymphoma, and warrants appropriate therapy.
- Publication
Cancer (0008543X), 1977, Vol 40, Issue 3, p1229
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197709)40:3<1229::AID-CNCR2820400337>3.0.CO;2-F