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- Title
Positron emission tomography in manganese intoxication.
- Authors
Wolters, E. Ch; Huang, C.-C.; Clark, C.; Peppard, R. F.; Okada, J.; Chu, N.-S.; Adam, M. J.; Ruth, T. J.; Li, D.; Calne, D. B.; Wolters, E C
- Abstract
We employed 6-fluorodopa to study the integrity of the nigrostriatal dopaminergic projection by positron emission tomography in 4 subjects with clinical features of mild parkinsonism caused by exposure to manganese. The 6-fluorodopa scans were normal. This finding suggests that in early manganism sufficient to cause parkinsonian deficits, damage may occur in pathways postsynaptic to the nigrostriatal system, probably involving striatal or pallidal neurons. Fluorodeoxyglucose scans showed decreased cortical glucose metabolism, the significance of which is discussed.
- Subjects
PARKINSON'S disease diagnosis; BRAIN metabolism; DOPA; BRAIN; CHRONIC diseases; COMPARATIVE studies; MAGNETIC resonance imaging; MANGANESE; RESEARCH methodology; MEDICAL cooperation; PARKINSON'S disease; RESEARCH; POSITRON emission tomography; EVALUATION research
- Publication
Annals of Neurology, 1989, Vol 26, Issue 5, p647
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.410260510