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- Title
Linkage of adrenoleukodystrophy to a polymorphic DNA probe.
- Authors
Aubourg, Patrick R.; Sack, George H.; Meyers, Deborah A.; Lease, John J.; Moser, Hugo W.
- Abstract
Linkage studies between X-linked adrenoleukodystrophy and a cloned deoxyribonucleic acid fragment (St14), which detects polymorphisms in the distal end of the long arm of the X chromosome (Xq27-28), have shown no recombination in six families. The lod score for these data (and another kindred reported earlier) [2] is 13.766 at recombination fraction (θ) = 0.0. These data permit assignment of adrenoleukodystrophy carrier status in family members at risk, supplementing the chemical measurement of very-long-chain fatty acids.
- Publication
Annals of Neurology, 1987, Vol 21, Issue 4, p349
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410210406