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- Title
Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels.
- Authors
Bonnet, F.; Balkau, B.; Malécot, J. M.; Picard, P.; Lange, C.; Fumeron, F.; Aubert, R.; Raverot, V.; Déchaud, H; Tichet, J.; Lecomte, P.; Pugeat, M.
- Abstract
Objective: Previous evidence has suggested that a low sex hormone-binding globulin (SHBG) concentration is associated with insulin-resistance and a low adiponectin concentration. We investigated the association between SHBG and the risk of hyperglycemia in each sex and we determined potential interactions between SHBG and adiponectin levels in the development of dysglycemia. Design: We used a nested case-control design in the large prospective study, Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). We studied 227 men and women who were normoglycemic at baseline but hyperglycemic at 3 years (glycemia≥6.1 mmol/l or type 2 diabetes). They were matched for sex, age, and body mass index with 227 subjectswho remained normoglycemic at 3 years. Results: At baseline, the concentration of SHBG was significantly lower in women who subsequently developed hyperglycemia than in those who remained normoglycemic, with no difference for men. In multiple regression, SHBG at baseline was as an independent determinant of plasma adiponectin levels, in bothwomen (P≤0.0001) and men (PZ0.002). In multivariate conditional logistic regression taking into account physical activity and changes in waist circumference over the follow-up, plasma SHBG remained significantly associated with the development of hyperglycemia in women but not in men. These associations persisted after adjustment for fasting insulinemia, high fasting glucose, and adiponectin levels. Conclusions: These findings suggest that a low SHBG level is a strong risk marker for dysglycemia in women, independently of both adiponectinemia and insulinemia. SHBG may therefore improve the identification of women at risk of diabetes.
- Subjects
SEX hormones; GLOBULINS; DISEASE incidence; HYPERGLYCEMIA; ADIPONECTIN; METABOLIC syndrome; DISEASES in women
- Publication
European Journal of Endocrinology, 2009, Vol 161, Issue 1, p81
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-09-0202