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- Title
Distribution and Intracellular Localization of a Mouse Homologue of Ca[sup 2+]/Calmodulin-Dependent Protein Kinase Iβ2 in the Nervous System.
- Authors
Ueda, Takahiro; Sakagami, Hiroyuki; Abe, Kuniya; Oishi, Isao; Maruo, Akihiro; Kondo, Hisatake; Terashima, Toshio; Ichihashi, Masamitsu; Yamamura, Hirohei; Minami, Yasuhiro
- Abstract
Abstract: Ca[sup 2+]/calmodulin-dependent protein kinases (CaMKs) are believed to play important roles in the development and function of the nervous system. We report here the identification and expression of mouse CaMKI beta (mCaMKI beta), in particular mCaMKI beta 2, an isoform of mCaMKI beta. During embryogenesis, the mCaMKI beta 2 gene is expressed mainly in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS, the expression of mCaMKI beta 2 is detected in the mantle zone, but not in the ventricular zone, suggesting its possible involvement in the differentiation of neurons. In the adult brain, mCaMKI beta 2 transcripts are detected at high levels in the anterior olfactory nuclei, piriform cortex, septal nuclei, bed nuclei of the stria terminalis, hippocampal pyramidal cells, dentate granule cells, amygdala, hypothalamic nuclei, parabrachial nucleus, and nucleus of the solitary tract. The distinct gene expression pattern suggests that mCaMKI beta 2 may also be involved in different mature neuronal functions from other CaMKs. In addition, mCaMKI beta 2 proteins are localized to the cytoplasm and nuclei, but not to nucleoli, suggesting that mCaMKI beta 2 proteins might be involved in the cytoplasmic and nuclear signal transduction of the nervous system. Key Words: Mouse...
- Subjects
PROTEIN kinases; NERVOUS system; GENE expression; NEURONS
- Publication
Journal of Neurochemistry, 1999, Vol 73, Issue 5, p2119
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1046/j.1471-4159.1999.02119.x