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- Title
Long-Term Outcomes of Chemoradiation for Anal Cancer Patients.
- Authors
Hun Jin Kim; Jung Wook Huh; Chang Hyun Kim; Sang Woo Lim; Taek-Keun Nam; Hyeong Rok Kim; Young Jin Kim
- Abstract
Purpose: The aim of this study was to evaluate long-term oncologic outcomes after concurrent chemoradiation treatment for anal cancer. Materials and Methods: Between January 1979 and December 2008, the records of 50 consecutive patients with anal cancer and who were treated by chemoradiation or radiation only with a curative intent were retrospectively reviewed. The oncologic outcomes and the risk factors for recurrence were analyzed. Results: Of the 50 patients, 49 underwent concurrent chemoradiation and one underwent radiation only. After these definitive treatments, 43 (86.0%) achieved a clinical complete response. During the median follow-up of 60 months (range: 2-202 months), the 5-year overall survival, disease-free survival, and locoregional recurrence-free survival were 84.2%, 72.7%, and 69.9%, respectively. Multivariate analysis revealed that the performance status (p=0.031) and a clinical complete response (p=0.039) were the independent predictors for overall survival; lymph node involvement (p=0.031) was the only independent predictor for disease-free survival. Conclusion: The performance status and a clinical complete response may be reliable predictors of survival after chemoradiation for anal cancer. The addition of irradiation to the inguinal area may not be significantly associated with the outcomes.
- Subjects
ANAL cancer treatment; CANCER prognosis; CANCER chemotherapy; HEALTH outcome assessment; RETROSPECTIVE studies; FOLLOW-up studies (Medicine); MEDICAL statistics
- Publication
Yonsei Medical Journal, 2013, Vol 54, Issue 1, p108
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2013.54.1.108