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- Title
m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats.
- Authors
MOSELHY, Said Salama; RAZVI, Syed Shoeb; ALSHIBILI, Fawzia A.; KUERBAN, Abudukadeer; HASAN, Mohammed Nihal; BALAMASH, Khadijah Saeed; HUWAIT, Etimad A.; ABDULAAL, Wesam H.; AL-GHAMDI, Maryam A.; KUMOSANI, Taha A.; ABULNAJA, Khalid Omar; AL-MALKI, Abdulrahman L.; Tadao ASAMI; ISMAIL, Iman M.
- Abstract
this study, we investigated the inhibitory effects of m-coumaric acid on the glycosylation of proteins in the retinas of diabetic rats. Male rats were divided into two main groups, Group I (normal control) and Group II (diabetic); Group II was further divided into four subgroups: Group IIa (diabetic control), Group IIb (diabetic rats were given m-coumaric acid orally [150 mg/kg, body weight (bw)/day]), Group IIc (diabetic rats were given HCA m-coumaric acid orally [300 mg/kg bw/day]), and Group IId (diabetic rats were given insulin [10 units/kg bw/day]) as a positive control). The treatment lasted for six weeks, and the data obtained suggested that m-coumaric acid reduced glucose and glycated hemoglobin levels, which further decreased the formation of glucose-derived advanced glycation end products. Hence, it protected the tissues from the detrimental effects of hyperglycemia and enhanced antioxidant activity. In conclusion, m-coumaric acid could be a potential candidate to prevent the onset and progression of retinopathy in diabetic patients.
- Subjects
GLYCOSYLATION; RETINA; HYPERGLYCEMIA; DIABETIC retinopathy; ANTIOXIDANTS
- Publication
Journal of Pesticide Science, 2018, Vol 43, Issue 3, p180
- ISSN
1348-589X
- Publication type
Article
- DOI
10.1584/jpestics.D17-091