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- Title
High-Intensity Resistance Exercise and Schinus terenbinthifolius Supplementation Attenuate Oxidative Stress and Muscle Damage Biomarkers.
- Authors
Marques Vieira-Souza, Lucio; Carlos Marçal, Anderson; Lopes dos Santos, Jymmys; José Aidar, Felipe; Bruno dos Santos, Samuel; de Santana Silva, André Luiz; Costa Reis, Gracielle; Santana de Carvalho, George Franklin; Fabrício de Souza, Raphael; Tavares dos Santos, Darlan; Sorbazo Soto, Dany Alexis; José Brito, Ciro
- Abstract
High-intensity physical exercises can cause oxidative stress and muscle damage. Several medicinal plants have been used as antioxidant and anti-inflammatory agents. The present study evaluated high-intensity resistance exercise (HIRE) associated with Schinus Terebentifholius ethanolic extract (EE) on oxidative parameters and muscle damage in Wistar rats. Animals were divided into 04 groups (n=10/group): 1. Control (CG) - animals that did not undergo HIRE and were treated with vehicle (distilled water, orally); 2. Acute exercise (AE) - animals submitted to acute exercise session; 3. Exercise + vehicle (EV) - animals that underwent HIRE and were treated with vehicle and 4. Exercise + extract (EX) animals administered with Schinus terebenthifolius EE (100mg/Kg, orally) and submitted to the exercise session. Schinus terebenthifolius EE showed high in vitro antioxidant activity (13.88 ± 0.36 mg/mL). Before the experimental period, lactate was measured at pre and post moments of AE (p<0.0001) and EX (p<0.0001) groups. After the acute session, the following were evaluated: oxidative stress {malondialdehyde (MDA), sulfhydryl groups (SH) and ferric reducing antioxidant power (FRAP)}, muscle damage (creatine kinase (CK) and lactate dehydrogenase (LDH)), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In the in vivo analyses of the EX group compared to AE and EV groups, respectively: hepatic (MDA: p<0.0001 and SH: p=0.0033, in both; FRAP: p=0.0011 and p=0.0047), muscle (MDA, SH and FRAP: p<0.0001, in both; CK: p=0.0001 and p<0.0001; LDH: p<0.0001, in both), serum levels (MDA: p=0.0003, p=0.0012, SH: p=0.0056, p=0.0200, FRAP: p=0.0017 and p=0.0165) were significant. There was no significant difference in ALT and AST markers. It could be concluded that Schinus terebenthifolius EE associated with HIRE attenuated oxidative stress and muscle damage in rats.
- Subjects
ISOMETRIC exercise; RESISTANCE training; OXIDATIVE stress; ALANINE aminotransferase; CREATINE kinase; ASPARTATE aminotransferase
- Publication
International Journal of Morphology, 2022, Vol 40, Issue 3, p781
- ISSN
0717-9367
- Publication type
Article
- DOI
10.4067/s0717-95022022000300781