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- Title
Lactate Dehydrogenase-Elevating Virus Infection Inhibits MOG Peptide Presentation by CD11b+CD11c+ Dendritic Cells in a Mouse Model of Multiple Sclerosis.
- Authors
Soe, Pyone Pyone; Gaignage, Mélanie; Mandour, Mohamed F.; Marbaix, Etienne; Van Snick, Jacques; Coutelier, Jean-Paul
- Abstract
Infections may affect the course of autoimmune inflammatory diseases of the central nervous system (CNS), such as multiple sclerosis (MS). Infections with lactate dehydrogenase-elevating virus (LDV) protected mice from developing experimental autoimmune encephalomyelitis (EAE), a mouse counterpart of MS. Uninfected C57BL/6 mice immunized with the myelin oligodendrocyte glycoprotein peptide (MOG35–55) experienced paralysis and lost weight at a greater rate than mice who had previously been infected with LDV. LDV infection decreased the presentation of the MOG peptide by CD11b+CD11c+ dendritic cells (DC) to pathogenic T lymphocytes. When comparing non-infected mice to infected mice, the histopathological examination of the CNS showed more areas of demyelination and CD45+ and CD3+, but not Iba1+ cell infiltration. These results suggest that the protective effect of LDV infection against EAE development is mediated by a suppression of myelin antigen presentation by a specific DC subset to autoreactive T lymphocytes. Such a mechanism might contribute to the general suppressive effect of infections on autoimmune diseases known as the hygiene hypothesis.
- Subjects
PEPTIDES; MYELIN oligodendrocyte glycoprotein; DENDRITIC cells; MULTIPLE sclerosis; CENTRAL nervous system diseases; VIRUS diseases
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 9, p4950
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25094950