We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Analysis of CT signs, radiomic features and clinical characteristics for delta variant COVID-19 patients with different vaccination status.
- Authors
Wei, Huanhuan; Shao, Zehua; Tai, Jianqing; Fu, Fangfang; Lv, Chuanjian; Guo, Zhiping; Wu, Yaping; Chen, Lijuan; Bai, Yan; Wu, Qingxia; Yu, Xuan; Mu, Xinling; Shao, Fengmin; Wang, Meiyun
- Abstract
Objective: To explore the characteristics of peripheral blood, high resolution computed tomography (HRCT) imaging and the radiomics signature (RadScore) in patients infected with delta variant virus under different coronavirus disease (COVID-19) vaccination status. Methods: 123 patients with delta variant virus infection collected from November 1, 2021 to March 1, 2022 were analyzed retrospectively. According to COVID-19 vaccination Status, they were divided into three groups: Unvaccinated group, partially vaccinated group and full vaccination group. The peripheral blood, chest HRCT manifestations and RadScore of each group were analyzed and compared. Results: The mean lymphocyte count 1.22 ± 0.49 × 10^9/L, CT score 7.29 ± 3.48, RadScore 0.75 ± 0.63 in the unvaccinated group; The mean lymphocyte count 1.55 ± 0.70 × 10^9/L, CT score 5.27 ± 2.72, RadScore 1.03 ± 0.46 in the partially vaccinated group; The mean lymphocyte count 1.87 ± 0.70 × 10^9/L, CT score 3.59 ± 3.14, RadScore 1.23 ± 0.29 in the fully vaccinated group. There were significant differences in lymphocyte count, CT score and RadScore among the three groups (all p < 0.05); Compared with the other two groups, the lung lesions in the unvaccinated group were more involved in multiple lobes, of which 26 cases involved the whole lung. Conclusions: Through the analysis of clinical features, pulmonary imaging features and radiomics, we confirmed the positive effect of COVID-19 vaccine on pulmonary inflammatory symptoms and lymphocyte count (immune system) during delta mutant infection.
- Subjects
SARS-CoV-2 Delta variant; VACCINATION status; COVID-19; LYMPHOCYTE count; VIRUS diseases; PLANT viruses; NEUROENDOCRINE cells
- Publication
BMC Medical Imaging, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2342
- Publication type
Article
- DOI
10.1186/s12880-022-00937-9