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- Title
Needle-free jet injection of DNA and protein vaccine of the Far-Eastern subtype of tick-borne encephalitis virus induces protective immunity in mice.
- Authors
Omori-Urabe, Yuki; Yoshii, Kentaro; Ikawa-Yoshida, Ayae; Kariwa, Hiroaki; Takashima, Ikuo
- Abstract
ABSTRACT Tick-borne encephalitis virus (TBEV) causes severe encephalitis in humans. It is endemic in one area of Japan; however no commercial vaccine is available in that country. In this Japan-based study, the efficacy of subviral particles (SPs) of TBEV administered by needle-free injector was evaluated as a vaccine candidate. Inoculation with SP-encoding DNA by needle-free injector induced neutralizing antibodies more efficiently than when administered by needle and syringe, and mice vaccinated with one dose by needle-free injector survived challenge with a lethal dose of TBEV. These results suggest that SP vaccines delivered by needle-free injector can protect against TBEV infection.
- Subjects
JAPAN; JET injections; DNA vaccines; TICK-borne encephalitis; TICK-borne diseases in animals; LABORATORY mice; VACCINATION
- Publication
Microbiology & Immunology, 2011, Vol 55, Issue 12, p893
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/j.1348-0421.2011.00389.x