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- Title
Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity.
- Authors
Xie, Qifei; Li, Suiji; Gao, Yun; Jin, Ling; Dai, Cuilian; Song, Juan
- Abstract
Phytomedicine has shown a promising potential for the prevention of cardiovascular system diseases and disorders. This study aimed to evaluate protective effect of ergosterol (ER) on isoproterenol (ISO)-induced myocardial cardiotoxicity. We found that pretreatment with ER significantly decreased levels of myocardial CK-MB and LDH, and alleviated myocardial damage induced by ISO in rat model. In addition, ER restored Nrf2 and HO-1 expression and inhibited apoptosis through upregulating Bcl-2 and downregulating Bax, cytochrome c, cleaved caspase-3, caspase-9, and PARP in rat hearts. Hypoxia-reoxygenation model in H9C2 cells confirmed the cardioprotective effects of ER. In conclusion, we provide both in vitro and in vivo evidence that ER significantly enhances Nrf2-mediated anti-oxidative activities, and exerts a protective effect on cardiomyocyte apoptosis. ER could be considered as a potential therapeutic agent to prevent myocardial injury.
- Subjects
INTERNATIONAL Organization for Standardization; MYOCARDIUM; CARDIOVASCULAR diseases; ERGOSTEROL; CARDIOTOXICITY; CYTOCHROME c; DISEASES
- Publication
Cardiovascular Toxicology, 2020, Vol 20, Issue 5, p500
- ISSN
1530-7905
- Publication type
Article
- DOI
10.1007/s12012-020-09574-6