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- Title
Immunostimulatory Activities of the Sulfated Polysaccharide Ascophyllan from Ascophyllum nodosum in in Vivo and in Vitro Systems.
- Authors
NAKANO, Kiyoaki; KIM, Daekyung; JIANG, Zedong; UENO, Mikinori; OKIMURA, Takasi; YAMAGUCHI, Kenichi; ODA, Tatsuya
- Abstract
The article discusses the findings of a study which determined the bioactivity of ascophyllan on splenic natural killer (NK) cells and RAW264.7 cells. It notes that the effects of ascophyllan were tested in vivo for NK cells, while it was in vitro cytotoxic analysis was done for the mouse macrophage RAW264.7 cells. The experiment confirmed ascophyllan's immunopotentiating characteristic through inducement of high nitric oxide (NO) levels in macrophages.
- Subjects
KILLER cells; CELL-mediated cytotoxicity; MACROPHAGES; NITRIC oxide; ASCOPHYLLUM nodosum
- Publication
Bioscience, Biotechnology & Biochemistry, 2012, Vol 76, Issue 8, p1573
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.120232