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- Title
A Novel Method of Screening Cell-Cycle Blockers as Candidates for Anti-Tumor Reagents Using Yeast as a Screening Tool.
- Authors
Tsuchiya, Eiko; Yukawa, Masashi; Ueno, Masaru; Kimura, Ken-Ichi; Takahashi, Hidetoshi
- Abstract
The article presents a study on the development of a screening method for cell-cycle blockers with the use of Saccharomyces cerevisiae yeast to determine the activity of substances by cell growth. The study showed that the mechanisms of eularyotic cell-cycle regulation are linked closely to cellular tumorgenesis. The screening tool indicates that it is effective as a first-screening system for anti-tumor agents.
- Subjects
SACCHAROMYCES cerevisiae; YEAST; GROWTH factors; TUMOR antigens; TUMOR markers
- Publication
Bioscience, Biotechnology & Biochemistry, 2010, Vol 74, Issue 2, p411
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.90633