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- Title
Diiminium Nucleophile Adducts Are Stable and Convenient Strong Lewis Acids.
- Authors
Bormann, Niklas; Ward, Jas S.; Bergmann, Ann Kathrin; Wenz, Paula; Rissanen, Kari; Gong, Yiwei; Hatz, Wolf‐Benedikt; Burbaum, Alexander; Mulks, Florian F.
- Abstract
Strong Lewis acids are essential tools for manifold chemical procedures, but their scalable deployment is limited by their costs and safety concerns. We report a scalable, convenient, and inexpensive synthesis of stable diiminium‐based reagents with a Lewis acidic carbon centre. Coordination with pyridine donors stabilises these centres; the 2,2'‐bipyridine adduct shows a chelation effect at carbon. Due to high fluoride, hydride, and oxide affinities, the diiminium pyridine adducts are promising soft and hard Lewis acids. They effectively produce acylpyridinium salts from carboxylates that can acylate amines to give amides and imides even from electronically intractable coupling partners.
- Subjects
LEWIS acids; AMIDES; IMIDES; CHELATION; PYRIDINE
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 58, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202302089