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- Title
Syntheses of Thailandepsin B Pseudo‐Natural Products: Access to New Highly Potent HDAC Inhibitors via Late‐Stage Modification.
- Authors
Brosowsky, Jana; Lutterbeck, Monika; Liebich, Amelie; Keller, Manfred; Herp, Daniel; Vogelmann, Anja; Jung, Manfred; Breit, Bernhard
- Abstract
New Thailandepsin B pseudo‐natural products have been prepared. Our synthetic strategy offers the possibility to introduce varying warheads via late stage modification. Additionally, it gives access to the asymmetric branched allylic ester moiety of the natural product in a highly diastereoselective manner applying rhodium‐catalyzed hydrooxycarbonylation. The newly developed pseudo‐natural products are extremely potent and selective HDAC inhibitors. The non‐proteinogenic amino acid d‐norleucine was obtained enantioselectively by a recently developed method of rhodium‐catalyzed hydroamination.
- Subjects
HISTONE deacetylase inhibitors; NEW product development; NATURAL products; MOIETIES (Chemistry); HYDROAMINATION
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 69, p16241
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202002449