We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Ru<sup>II</sup> Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy.
- Authors
Hu, Xiaochun; Lu, Yonglin; Dong, Chunyan; Zhao, Wenrong; Wu, Xuewen; Zhou, Lulu; Chen, Lv; Yao, Tianming; Shi, Shuo
- Abstract
Despite drug delivery nanoplatforms receiving extensive attention, development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. Herein, a versatile nanoplatform based on a zirconium framework (UiO‐66‐N3) was synthesized, which demonstrated a combined photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT) for cancer treatment. A RuII polypyridyl alkyne complex (Ra) as a photosensitizer was modified into a nanoplatform by click reactions for the first time. When exposed to suitable light irradiation, the as‐prepared multifunctional nanoplatform (UiO‐Ra‐DOX‐CuS) not only demonstrated efficient 1O2 generation, but also exhibited excellent photothermal conversion ability. In particular, the nanotherapeutic agent presented a dual‐stimuli response; either acidic environment or NIR laser irradiation would trigger the drug release. The synergetic efficacy of UiO‐Ra‐DOX‐CuS combined PDT, PTT, and CT, which was evaluated by cell experiments. Moreover, the design could promote the development of RuII polypyridyl alkyne complexes based multifunctional nanoparticles and multimodal cancer treatment.
- Subjects
METAL-organic frameworks; CANCER chemotherapy; COMBINED modality therapy; PHOTOTHERMAL conversion; CANCER treatment; PLATINUM
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 7, p1668
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201904704