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- Title
Naphtho[1,2- b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways.
- Authors
Tsai, Pei-Chien; Chu, Chiao-Lun; Fu, Yaw-Syan; Tseng, Chih-Hua; Chen, Yeh-long; Chang, Long-Sen; Lin, Shinne-Ren
- Abstract
Naphtho[1,2- b]furan-4,5-dione (NFD), a bioactive component of Avicennia marina, has been demonstrated to display anti-cancer activity. Breast cancer is a highly malignant carcinoma and most deaths of breast cancer are caused by metastasis. In this study, we showed that NFD blocked migration and invasion of MDA-MB-231 breast cancer cells without affecting apoptosis or growth arrest. NFD caused significant block of Src kinase activity in MDA-MB-231 cells. Moreover, NFD treatment was correlated with reduced phosphorylation of FAK at Tyr 576/577, 861 and 925 sites, p130 at Tyr 410, and paxillin at Tyr 118. NFD also suppressed the activation of phosphatidylinositol 3-kinase/Akt. Consistent with inhibition of these signaling pathways and invasion, NFD reduced the expression of matrix metalloproteinase-9. Furthermore, Src antagonist PP2 caused a significant decrease in the phosphorylation of FAK, p130, paxillin, and PI3K/Akt. Our findings provide evidences that NFD inhibits Src-mediated signaling pathways involved in controlling breast cancer migration and invasion, suggesting that it has a therapeutic potential in breast cancer treatment.
- Subjects
CELL migration; AVICENNIA; METALLOPROTEINASES; PHOSPHORYLATION; PHOSPHATIDYLINOSITOL 3-kinases
- Publication
Molecular & Cellular Biochemistry, 2014, Vol 387, Issue 1/2, p101
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-013-1875-4