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- Title
Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events.
- Authors
K. Abe; H. Yoshimura; H. Tanaka; N. Fujita; T. Hikita; S. Sakoda
- Abstract
The mechanism of neurological disturbances in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is controversial. We studied 12 patients with MELAS using conventional and diffusion weighted MRI (DWI) and MR spectroscopy (MRS), to look at the physiopathology of the stroke-like events. Although conventional MRI showed lesions in all patients, DWI was more sensitive. One patient did not show high signal on DWI 48 h after a from stroke-like episode, but MRS demonstrated a lactate peak in left occipital lobe; 2 weeks after the attack, high signal was demonstrated on the right frontal lobe where MRS had shown a lactate peak. Our findings suggest a possible predictive ability of 1H-MRS, in showing early MELAS lesions and supports the hypothesis that mitochondrial metabolic dysfunction may precedes abnormalities on DWI.
- Subjects
MAGNETIC resonance imaging; PROTON magnetic resonance spectroscopy; ACIDOSIS; CEREBROVASCULAR disease
- Publication
Neuroradiology, 2004, Vol 46, Issue 2, p113
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-003-1138-2