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- Title
A feasibility study of outpatient chemotherapy with S-1 + cisplatin in patients with advanced gastric cancer.
- Authors
Okazaki, Shunsuke; Nakajima, Takako; Hashimoto, Jun; Yamamoto, Seiichiro; Takahari, Daisuke; Kato, Ken; Hamaguchi, Tetsuya; Yamada, Yasuhide; Shimada, Yasuhiro; Tamura, Kenji
- Abstract
Background: Regimens of standard-dose cisplatin have usually been administered as inpatient chemotherapy in Japan. This prospective study evaluated the feasibility of outpatient chemotherapy with standard-dose cisplatin in Japanese patients with advanced gastric cancer. Methods: Advanced gastric cancer patients received an S-1 + cisplatin regimen (S-1: 80-120 mg days 1-21; cisplatin: 60 mg/m day 8, every 4-5 weeks), either as outpatient chemotherapy with oral hydration on days 9-10, or as inpatient chemotherapy with intravenous hydration on days 9-10, based on the results of an oral hydration test during days 1-7 of the first cycle. The primary endpoint was the completion rate of two cycles in the outpatient group. Results: A total of 36 patients were enrolled: 32 were allocated to the outpatient group and 4 to the inpatient group. The completion rate of two cycles in the outpatient group was 78% [90% confidence interval (CI): 63-89]. The median of the total number of treatment cycles of S-1 + cisplatin and the median progression-free survival in the outpatient group were 5 (range 1-11) and 10.6 months (95% CI 4.2-16.9), respectively. Although seven patients in the outpatient group discontinued treatment, mainly owing to gastrointestinal toxicity, most of them could continue S-1 + cisplatin by switching to inpatient chemotherapy from the next cycle. Conclusion: Outpatient chemotherapy with S-1 + cisplatin in advanced gastric cancer patients can be safely and effectively administered in Japan with appropriate patient selection and supportive treatment.
- Subjects
OUTPATIENT services in hospitals; DRUG therapy; CISPLATIN; GASTROINTESTINAL cancer; HYDRATION; CONFIDENCE intervals
- Publication
Gastric Cancer, 2013, Vol 16, Issue 1, p41
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-012-0139-4