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- Title
Immunohistochemical localization of Bis protein in the rat central nervous system.
- Authors
Hyun-Jung Park; Jeong-Sun Choi; Myung-Hoon Chun; Jin-Woong Chung; Mi-Hee Jeon; Jeong-Hwa Lee; Mun-Yong Lee
- Abstract
We studied the distribution of Bis (Bcl-2 interacting death suppressor) protein in the adult rat brain and spinal cord using immunohistochemistry. Immunoreactivity was observed in specific neuronal populations in distinct nuclei. The most intensely labeled cells were associated with the motor system, including most cranial nerve motor nuclei, Purkinje cells of the cerebellum, the red nucleus, and the ventral motor neurons of the spinal cord. Bis protein was also expressed in several structures associated with the ventricular system, including the subventricular zone of the lateral ventricle and its rostral extension, in the subcommissural organ, and in tanycytes, radial glial cells in the hypothalamus. Using double-labeling techniques, Bis-immunoreactive cells in the rostral migratory stream, coexpressing Bcl-2, were confirmed as glial fibrillary acidic protein-positive astrocytes comprising the glial tubes. The widespread distribution of Bis suggests that this protein has broader functions in the adult rat central nervous system than previously thought, and that it could be associated with a particular role in the rostral migratory system.
- Subjects
LABORATORY rats; NERVOUS system; HYPOTHALAMUS; CELL nuclei; IMMUNOHISTOCHEMISTRY; NEUROGLIA; ENDOCRINE glands
- Publication
Cell & Tissue Research, 2003, Vol 314, Issue 2, p207
- ISSN
0302-766X
- Publication type
Article
- DOI
10.1007/s00441-003-0786-1