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- Title
Sonographic measurement of the fetal iliac angle cannot be used alone as a marker for trisomy 21.
- Authors
Grangé, Gilles; Thoury, Anne; Dupont, Jean-Michel; Pannier, Emmanuelle; LeRhun, Françoise; Goussot Souchet, Michèle; Goffinet, François; Cabrol, Dominique; Grangé, G; Thoury, A; Dupont, J; Pannier, E; LeRhun, F; Goussot Souchet, M; Goffinet, F; Cabrol, D
- Abstract
The fetal iliac wings angle was studied in 255 fetuses before amniocentesis at 16.7 weeks (+/- 1.3), using a sonographic axial view of the fetal pelvis. The measurement could be performed in 208 fetuses (81.6%), of whom 4 had trisomy 21 (T 21). The mean iliac angle was greater in fetuses with T 21 than in normal fetuses (69.8 degrees vs. 88.7 degrees; p = 0.03). This measurement is subject to significant intra- and interexaminer variability (interclass correlation coefficient: 0.65 and 0.23, respectively). When a 90 degrees value is used as a threshold, specificity, sensitivity, positive and negative predictive values are, respectively, 80, 75, 7. 0 and 99.4%. The 20% rate of false-positives rules out the use of this measurement as the sole criterion for the indication of amniocentesis for T 21 antenatal diagnosis.
- Publication
Fetal Diagnosis & Therapy, 2000, Vol 15, Issue 1, p41
- ISSN
1015-3837
- Publication type
journal article
- DOI
10.1159/000020973