We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Evaluation of oxygen uptake kinetics and oxygen kinetics of peripheral skeletal muscle during recovery from exercise in patients with chronic obstructive pulmonary disease.
- Authors
Okamoto, Takashi; Kanazawa, Hiroshi; Hirata, Kazuto; Yoshikawa, Junichi
- Abstract
Summary The biochemical features of skeletal muscle and its contribution to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) is under active investigation. Near-infrared spectroscopy (NIRS) can non-invasively provide information on the oxidative capacity of muscle. To clarify whether oxygenation of peripheral muscle is one determinant of exercise tolerance, we simultaneously examined the oxygen uptake (&formmu1;) kinetics and oxygen kinetics of peripheral skeletal muscle evaluated by NIRS during recovery from exercise in COPD patients. Fifteen patients with COPD and five normal control subjects performed a symptom-limited incremental exercise test. On the following day, all patients performed a constant work rate exercise test while being monitored using NIRS continuously for changes in concentration of oxygenated haemoglobin (Hb[sub O[sub 2] ] ) and during expired gas analysis. We found that the time constant of &formmu2; during recovery from constant work rate exercise (&formmu3;) and the time constant of Hb[sub O[sub 2] ] during recovery (τ Hb[sub O[sub 2off] ] ) were significantly longer in COPD patients than in normal control subjects. &formmu4; was inversely correlated with absolute values of forced expiratory volume in 1 s (FEV[sub 1·0] ) and FEV[sub 1·0] (% predicted). However, no significant correlation was found between &formmu5; and FVC (forced vital capacity), FEV[sub 1·0] /FVC, or diffusing capacity of the lung for CO (DL[sub CO] ). Moreover, &formmu6; was inversely correlated with maximal &formmu7; and maximal work rate. In contrast, &formmu8; exhibited a significant positive correlation with τ Hb[sub O[sub 2off] ] . These results indicate that &formmu9; kinetics during recovery is related to re-oxygenation of peripheral skeletal muscle evaluated by NIRS in patients with COPD. Therefore, NIRS may be a useful tool to estimate the impairment of cardiopulmonary responses and re-oxygenation of peripheral skeletal muscle during the immediate recovery phase after exercise in COPD patients.
- Subjects
OXYGEN therapy; MUSCLES; OBSTRUCTIVE lung diseases; EXERCISE tests
- Publication
Clinical Physiology & Functional Imaging, 2003, Vol 23, Issue 5, p257
- ISSN
1475-0961
- Publication type
Article
- DOI
10.1046/j.1475-097X.2003.00500.x