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- Title
Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG.
- Authors
Chen, Chun-Yuan; Rao, Shan-Shan; Tan, Yi-Juan; Luo, Ming-Jie; Hu, Xiong-Ke; Yin, Hao; Huang, Jie; Hu, Yin; Luo, Zhong-Wei; Liu, Zheng-Zhao; Wang, Zhen-Xing; Cao, Jia; Liu, Yi-Wei; Li, Hong-Ming; Chen, Yang; Du, Wei; Liu, Jiang-Hua; Zhang, Yan; Chen, Tuan-Hui; Liu, Hao-Ming
- Abstract
Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells (USCs), which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles (USC-EVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition (with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1 (CTHRC1) and osteoprotegerin (OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG.
- Subjects
STEM cells; OSTEOPOROSIS prevention; URINE; OSTEOPROTEGERIN; OSTEOCLASTOGENESIS
- Publication
Bone Research, 2019, Vol 7, Issue 1, pN.PAG
- ISSN
2095-4700
- Publication type
Article
- DOI
10.1038/s41413-019-0056-9