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- Title
Structural, Vibrational, and Electronic Properties of the Glucoalkaloid Strictosidine: A Combined Experimental and Theoretical Study.
- Authors
Costa, Renyer Alves; Pinheiro, Maria Lucia Belem; Oliveira, Kelson Mota Teixeira de; Barison, Andersson; Salomé, Kahlil Schwanka; Iank, Júlio Rodolfo; da Silva, Noam Gadelha; Cabral, Tiara Souza; Costa, Emmanoel Vilaça
- Abstract
A detailed structural analysis and spectral behavior of the glucoalkaloid strictosidine, a precursor of all monoterpene indole alkaloids, are discussed. The experimental NMR, FTIR, and UV results were compared to the theoretical DFT spectra calculated by Becke using the three-parameter Lee-Yang-Parr (B3LYP) function with 6-31G(d) and 6-311++G(2d,p) basis sets. The theoretical geometry optimization data were compared with the X-ray data for precursors and similar structures in the associated literature. The similarity between the theoretical and experimental coupling constants values made it possible to affirm the values of dihedral angles and their configuration, reinforcing findings from previous stereochemical studies. Theoretical UV analysis agreed well with the measured experimental data, with bands assigned. Calculated HOMO/LUMO gaps show low excitation energy for strictosidine, justifying its stability and reaction kinetics. The molecular electrostatic potential map shows opposite potentials regions that form hydrogen bonds that stabilize the dimeric form, which were confirmed by excellent agreement of the dimeric form theoretical wavenumbers with the experimental IR spectrum. ESI-MS/MS data revealed patterns for the fragmentation of the protonated strictosidine molecule outlined by an NBO study.
- Subjects
ALKALOIDS; STRICTOSIDINE; CHEMICAL precursors; MONOTERPENES; INDOLE alkaloids; FOURIER transform infrared spectroscopy
- Publication
Journal of Chemistry, 2016, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2016/1752429