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- Title
Androgen sensitivity in COVID‐19 and antiandrogens: Prospective data are still needed.
- Authors
Ianhez, Mayra; Ramos, Paulo Müller; Goren, Andy; Miot, Hélio Amante
- Abstract
Androgen sensitivity in COVID-19 and antiandrogens: Prospective data are still needed In contrast, prepubescents appear to be largely protected from COVID-19 severe symptoms.1 The androgen receptor regulates the transcription of the transmembrane protease, serine 2 (TMPRSS2), and angiotensin converting enzyme 2 (ACE2) which are required for the COVID-19 infectivity; thus, raising the hypothesis of androgen sensitivity as a risk factor.2,3 The recent association of androgenetic alopecia (AGA) with COVID-19 severity strengthens the androgen theory.2 Testosterone levels are low not only in prepubescents but also in elderly men4 and recent observations point out that disease severity may be best correlated with specific gene loci, rather than ACE2 or TMPRSS2 receptors.5 Furthermore, serum androgens do not always correlate with tissue androgens or androgen mediated disease. For example, AGA and prostate cancer can be exacerbated by elevated tissue androgen in genetically predisposed patients.6 In order to elucidate the effect of androgens on COVID-19 outcomes, some epidemiological studies were conducted.
- Subjects
COVID-19; ANTIANDROGENS; ANDROGENS; COVID-19 pandemic; ANGIOTENSIN converting enzyme
- Publication
Dermatologic Therapy, 2020, Vol 33, Issue 6, p1
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/dth.14166