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- Title
Human interferon-α increases immobility in the forced swimming test in rats.
- Authors
Makino, M.; Kitano, Y.; Komiyama, C.; Takasuna, K.
- Abstract
Abstract Objectives: We examined the immobility of the forced swimming test induced in an animal model by human interferon (IFN), which has often been reported to induce depression in clinical use. Methods: In the present study, we examined the effects of human IFNs on results of the forced swimming test in rats. Results: Single intravenous (IV) administration of human IFN-alpha(6x10[sup 4] IU/kg), but not of human IFN-beta or -gamma, significantly increased immobility time in the forced swimming test in rats. Repeated administration of human IFN-alpha (6x10[sup 3] IU/kg) also significantly increased the immobility time. On the other hand, none of the rat IFNs (rat IFN-alpha, -beta and -gamma, 6x10[sup 4] IU/kg, IV) changed the immobility time. Neither human IFNs nor rat IFNs changed the locomotor activity of rats. Conclusions: These findings suggest that human IFN-alpha has a greater potential for inducing increase of the immobility in the rat forced swimming test than human IFN-beta and -gamma, and that the effect of human IFN-alpha might not be mediated through IFN-alpha/beta receptors.
- Subjects
PHYSIOLOGICAL effects of swimming; INTERFERONS; RATS; MENTAL depression; SCIENTIFIC experimentation
- Publication
Psychopharmacology, 2000, Vol 148, Issue 1, p106
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130050031